Figure 6. CC223 inhibits SKOV3 tumor growth in nude mice.

Randomly-assigned nude mice (n = 8 per group) bearing SKOV3 xenograft tumor were administrated (via gavage) with CC223 (15 or 50 mg/kg body weight, daily) or vehicle control (“Vehicle”) for 16 consecutive days; Tumor volume (A) and mice body weight (C) were recorded every 5 days for total 40 days; Estimated daily tumor growth (in mm³ per day) was also presented (B); *p < 0.05 vs. “Vehicle”. ^# p < 0.05 vs. CC223 at 15 mg/kg.