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. 2017 Apr 11;8(35):58480–58493. doi: 10.18632/oncotarget.17024

Figure 7. Schematic representation of the signaling pathways probably involved in osthole-mediated breast cancer bone metastasis.

Figure 7

Osthole inhibited breast cancer cell growth, migration, and invasion, and induced apoptosis of breast cancer cells in vitro. Additionally, it probably regulated TGF-β/SMADs signaling in the metastasis of breast to bone cancer in MDA-231BO cells. Besides, it also altered pro-metastatic / bone metabolic genes and regulated OPG/RANKL signals in the interactions between bone cells (osteoblasts and osteoclasts) and cancer cells in vivo. The green and yellow symbols indicate the inhibitory and promoting effects of osthole, respectively. Abbreviations: IL-8, interleukin-8; M-CSF, macrophage colony-stimulating factor; OPG, osteoprotegerin; PTHrP, parathyroid hormone-related peptide; RANKL, receptor activator of nuclear factor kappa-B ligand; TGF-β, transforming growth factor-beta.