Figure 3. Efficacy of GSK2126458 and rapamycin on renal tumours in Tsc2^+/- mice.

Tsc2^+/- mice were treated from 12 months old for 2 months (n=10 each group). Mice were sacrificed for tumour burden assessment at the age of 14 months. Dosages are described in methods. Kidney sections were prepared for histological assessment of treatment efficacy. Left panel: comparison of total number and size (area) as well as cellular area of all lesions (cystic, papillary and solid). Right panel: comparison of total number and size (area) as well as cellular area of solid tumours. Horizontal bars indicate a median. For detailed statistical analysis see Supplementary Tables 1 and 2.