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. 2017 Apr 24;8(35):58611–58624. doi: 10.18632/oncotarget.17381

Figure 6. PPA1 enhances cancer cell viability through inhibiting JNK signaling pathways.

Figure 6

(A) CCK-8 assay showed that PPA1 transfection enhanced the cell proliferation of cancer cells, while no significant effect was identified upon PPA1 inactive mutant transfection. In contrast, PPA1-silencing significantly down-regulated the cell proliferation, while JNK inhibitor can impair this antiproliferation effect. (B) Western Blot results demonstrated that PPA1 can modulate p53, Bax, p-Bcl-2 and cleaved Caspase-3 levels by recruiting JNK as an intermediate signaling molecular. Histogram showed the quantification results calculated by Image J Software from three experiments. (C) Schematically illustrations about the possible molecular and pathways involved in the PPA1 functions towards cancer transformation and development.