Table 2. Univariate and multivariate analysis of clinicopathological parameters associated with metastasis-free survival in osteosarcoma patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Gender (male vs. female) | 1.040(0.524-2.065) | 0.910 | ||
| Age (≤20 vs. >20 years) | 0.624(0.302-1.287) | 0.201 | ||
| Tumor location | 0.849(0.627-1.150) | 0.290 | ||
| Histological classification | 0.647(0.389-1.078) | 0.095 | ||
| Enneking stage (I +II vs III) | 7.122(3.285-15.441) | <0.001 | 3.679(1.609-8.413) | 0.002 |
| Lung metastasis (yes vs. no) | 13.285(4.534-38.932) | <0.001 | 10.019(3.263-30.765) | <0.001 |
| BMPR2 (high vs. low) | 2.493(1.161-5.353) | 0.019 | 1.832(1.008-3.925) | 0.041 |