Table 3. Univariate and multivariate analysis of clinicopathological parameters associated with overall survival in osteosarcoma patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Gender (male vs. female) | 1.142(0.606-2.151) | 0.682 | ||
| Age (≤20 vs. >20 years) | 0.934(0.495-1.761) | 0.833 | ||
| Tumor location | 0.947(0.722-1.240) | 0.691 | ||
| Histological classification | 0.792(0.521-1.203) | 0.274 | ||
| Enneking stage (I +II vs III) | 9.005(4.218-19.225) | <0.001 | 5.949(2.605-13.586) | <0.001 |
| Lung metastasis (yes vs. no) | 5.962(2.771-12.831) | <0.001 | 4.824(2.085-11.161) | <0.001 |
| BMPR2 (high vs. low) | 2.419(1.227-4.771) | 0.011 | 2.013(1.045-4.162) | 0.037 |