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. 2017 Apr 25;8(35):58654–58667. doi: 10.18632/oncotarget.17414

Figure 4. HOTAIR binds to SAV1 and activates the Hippo pathway.

Figure 4

(A) Restoration of SAV1 expression in 786O and OSRC2 cells. (B and C) Restoring SAV1 expression or inhibiting EZH2 attenuated the effect of HOTAIR on promoting cell proliferation. (D and E) SAV1 overexpression inhibited the migration of 786O and OSRC2 cells, similar to treatment with GSK503. (F, G, H and I) Hippo pathway activation was reversed by restoration of SAV1 or GSK503 treatment in 786O and OSRC2 cells. (J, and K) Restoration of SAV1 and treatment with EZH2 inhibitor inactivated the Hippo pathway.