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. 2017 Apr 28;8(35):58699–58708. doi: 10.18632/oncotarget.17506

Table 2. Univariable and multivariable Cox regression analyses in each data set.

Variables Univariable modela Multivariable model
HR 95% CI of HR P value HR 95% CI of HR P value
Training set (n=220)
Five-lncRNA risk score 1.151 1.104-1.200 <0.001 1.131 1.086-1.178 <0.001
Age 1.019 1.001-1.038 0.034 1.021 1.002-1.040 0.032
Gender 1.016 0.654-1.580 0.943 0.780 0.491-1.238 0.291
AJCC stage 3.675 2.323-5.816 <0.001 3.390 2.104-5.449 <0.001
Tumor grade 2.820 1.718-4.630 <0.001 1.752 0.999-3.071 0.050
Testing set (n=220)
Five-lncRNA risk score 1.057 1.011-1.104 0.014 1.055 1.014-1.098 <0.001
Age 1.040 1.017-1.063 <0.001 1.041 1.017-1.066 <0.001
Gender 0.904 0.540-1.513 0.701 1.339 0.777-2.309 0.294
AJCC stage 5.121 2.908-9.016 <0.001 4.440 2.419-8.150 <0.001
Tumor grade 2.374 1.326-4.252 0.004 1.542 0.834-2.852 0.167
Entire set (n=440)
Five-lncRNA risk score 1.106 1.073-1.139 <0.001 1.093 1.063-1.125 <0.001
Age 1.029 1.015-1.044 <0.001 1.030 1.015-1.045 <0.001
Gender 0.958 0.685-1.339 0.802 0.964 0.678-1.371 0.179
AJCC stage 4.217 2.956-6.015 <0.001 3.269 2.232-4.787 <0.001
Tumor grade 2.582 1.770-3.767 <0.001 1.675 1.121-2.501 0.012

a In both univariable and multivariable Cox regression analyses, risk score, age, gender, AJCC stage and Tumor grade were evaluated as continuous variables. P<0.05 was considered statistically significant in all analyses.