Figure 5. CIP2A/c-Myc pathway is involved in lapatinib-induced cell cycle regulation.

(A) SKBR3 and 78617 cells were treated with lapatinib for 16 hours, followed by Western blot analysis. Control or CIP2A-overexpressing SKBR3 and 78617 cells were treated with lapatinib (0.3 μM) for 16 hours, then examined using Western blot (B) and cell cycle (C) analyses.