Figure 3. Mutation distribution in the exons and functional domains of NOTCH1.

Each arrowhead represents a nonsynonymous mutation in an individual tumor. Individual exons are represented as numbered boxes. Conserved domains were mapped from UniProt. EGF-like, epidermal growth factor-like; LNR, Lin12/Notch repeats; HD^N, heterodimerization–N terminal; HD^C, heterodimerization–C terminal; TM, transmembrane; RAM, Rbp-associated molecule; Ankyrin, CDC10/ankyrin domain; TAD, transactivation domain; and PEST, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).