Figure 4. Genetic alterations identified by the sequencing of 409 cancer-related genes across 47 OSCCs impact cell cycle regulation and the RTK-MAPK-PI3K pathways.

Each column denotes an individual tumor, and each row represents a gene. Somatic alterations are colored by the type of the event. A major proportion of patients with OSCC harbored alterations in one or more components in the pathways of cell cycle regulation (87.2%) and RTK-MAPK-PI3K signaling (70.2%).