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. 2017 Jul 17;8(35):59123–59135. doi: 10.18632/oncotarget.19289

Figure 4. Mifepristone reduces expression of MMP-2, MMP-9, COX-2 and VEGF, and the related cell invasion in SKOV-3 and IGROV-1 cells.

Figure 4

(A) Mifepristone suppressed SDF-1-increased MMP-2 and MMP-9 mRNA levels. (B) Mifepristone down-regulated SDF-1-elevated protein levels of MMP-2, MMP-9, COX-2 and VEGF in a concentration-dependent manner. The immunoblot images and the related quantitative analysis were showed on the upper panel and lower panel, respectively. (C) Mifepristone inhibited SDF-1-promoted cell invasion. The SDF-1 effect was antagonized by AMD3100. *, P < 0.05; **, P < 0.01. Values = Mean ± SD. n = 3.