Table 3. Diagnostic accuracy of different indexes for the prediction of liver fibrosis in the CHB patients.

	Optimized cutoff	Sensitivity (%)	Specificity (%)	AUC (95%CI)	LR +	LR -	P value	P value of ROC contrast test*
F0-F1 vs. F2-F4
APRI	0.544	65.47	70.59	0.692 (0.626, 0.758)	2.226	0.489	<0.001	0.038
FIB-4	1.205	68.16	71.76	0.738 (0.678, 0.799)	2.414	0.444	<0.001	0.500
AAR	0.802	60.54	63.53	0.616 (0.549, 0.683)	1.660	0.621	0.002	0.002
GPR	0.432	60.09	70.59	0.657 (0.590, 0.724)	2.043	0.565	<0.001	0.001
RPR	0.070	70.85	63.53	0.681 (0.614, 0.747)	1.943	0.459	<0.001	0.006
APRG	0.695	73.54	68.24	0.757 (0.699, 0.816)	2.316	0.388	<0.001	—
F0-F2 vs. F3-F4
APRI	0.667	58.52	75.00	0.689 (0.630, 0.749)	2.341	0.553	<0.001	0.012
FIB-4	1.086	77.84	59.09	0.719 (0.661, 0.777)	1.903	0.375	<0.001	0.093
AAR	0.917	42.61	67.42	0.535 (0.470, 0.600)	1.308	0.851	0.295	<0.001
GPR	0.413	71.59	69.70	0.737 (0.681, 0.794)	2.363	0.408	<0.001	0.383
RPR	0.090	48.30	82.58	0.686 (0.626, 0.746)	2.773	0.626	<0.001	0.002
APRG	0.777	63.64	78.03	0.763 (0.711, 0.816)	2.897	0.466	<0.001	—
F0-F3 vs. F4
APRI	0.667	64.71	66.02	0.676 (0.612, 0.740)	1.904	0.535	<0.001	<0.001
FIB-4	1.602	65.69	71.84	0.723 (0.663, 0.783)	2.333	0.478	<0.001	0.034
AAR	0.767	73.53	45.15	0.574 (0.509, 0.640)	1.341	0.586	0.034	<0.001
GPR	0.482	74.51	67.96	0.758 (0.702, 0.814)	2.326	0.375	<0.001	0.458
RPR	0.070	85.29	50.49	0.709 (0.647, 0.771)	1.723	0.291	<0.001	0.009
APRG	0.787	70.59	71.36	0.781 (0.728, 0.835)	2.465	0.412	<0.001	—

AUROC: area under the receiver operating characteristic curve; CI: confidence interval; LR-: negative likelihood ratio; LR+: positive likelihood ratio; AAR: aspartate aminotransferase to alanine aminotransferase ratio; APRI: aspartate aminotransferase to platelet ratio index; FIB-4: fibrosis index based on the four factors; GPR: gamma-glutamyl transpeptidase to platelet ratio; RPR: red cell distribution width to platelet ratio.