Table 3. Diagnostic accuracy of different indexes for the prediction of liver fibrosis in the CHB patients.
Optimized cutoff | Sensitivity (%) | Specificity (%) | AUC (95%CI) | LR + | LR - | P value | P value of ROC contrast test* | |
---|---|---|---|---|---|---|---|---|
F0-F1 vs. F2-F4 | ||||||||
APRI | 0.544 | 65.47 | 70.59 | 0.692 (0.626, 0.758) | 2.226 | 0.489 | <0.001 | 0.038 |
FIB-4 | 1.205 | 68.16 | 71.76 | 0.738 (0.678, 0.799) | 2.414 | 0.444 | <0.001 | 0.500 |
AAR | 0.802 | 60.54 | 63.53 | 0.616 (0.549, 0.683) | 1.660 | 0.621 | 0.002 | 0.002 |
GPR | 0.432 | 60.09 | 70.59 | 0.657 (0.590, 0.724) | 2.043 | 0.565 | <0.001 | 0.001 |
RPR | 0.070 | 70.85 | 63.53 | 0.681 (0.614, 0.747) | 1.943 | 0.459 | <0.001 | 0.006 |
APRG | 0.695 | 73.54 | 68.24 | 0.757 (0.699, 0.816) | 2.316 | 0.388 | <0.001 | — |
F0-F2 vs. F3-F4 | ||||||||
APRI | 0.667 | 58.52 | 75.00 | 0.689 (0.630, 0.749) | 2.341 | 0.553 | <0.001 | 0.012 |
FIB-4 | 1.086 | 77.84 | 59.09 | 0.719 (0.661, 0.777) | 1.903 | 0.375 | <0.001 | 0.093 |
AAR | 0.917 | 42.61 | 67.42 | 0.535 (0.470, 0.600) | 1.308 | 0.851 | 0.295 | <0.001 |
GPR | 0.413 | 71.59 | 69.70 | 0.737 (0.681, 0.794) | 2.363 | 0.408 | <0.001 | 0.383 |
RPR | 0.090 | 48.30 | 82.58 | 0.686 (0.626, 0.746) | 2.773 | 0.626 | <0.001 | 0.002 |
APRG | 0.777 | 63.64 | 78.03 | 0.763 (0.711, 0.816) | 2.897 | 0.466 | <0.001 | — |
F0-F3 vs. F4 | ||||||||
APRI | 0.667 | 64.71 | 66.02 | 0.676 (0.612, 0.740) | 1.904 | 0.535 | <0.001 | <0.001 |
FIB-4 | 1.602 | 65.69 | 71.84 | 0.723 (0.663, 0.783) | 2.333 | 0.478 | <0.001 | 0.034 |
AAR | 0.767 | 73.53 | 45.15 | 0.574 (0.509, 0.640) | 1.341 | 0.586 | 0.034 | <0.001 |
GPR | 0.482 | 74.51 | 67.96 | 0.758 (0.702, 0.814) | 2.326 | 0.375 | <0.001 | 0.458 |
RPR | 0.070 | 85.29 | 50.49 | 0.709 (0.647, 0.771) | 1.723 | 0.291 | <0.001 | 0.009 |
APRG | 0.787 | 70.59 | 71.36 | 0.781 (0.728, 0.835) | 2.465 | 0.412 | <0.001 | — |
AUROC: area under the receiver operating characteristic curve; CI: confidence interval; LR-: negative likelihood ratio; LR+: positive likelihood ratio; AAR: aspartate aminotransferase to alanine aminotransferase ratio; APRI: aspartate aminotransferase to platelet ratio index; FIB-4: fibrosis index based on the four factors; GPR: gamma-glutamyl transpeptidase to platelet ratio; RPR: red cell distribution width to platelet ratio.