Table 2. Correlations between PATZ1 and the proneural and mesenchymal signature in GBMa.
| Proneural signature | Mesenchymal signature | ||||
|---|---|---|---|---|---|
| Gene | rb | p | gene | r | p |
| CHD7 | 0.649 | 3.9e-62 | HEXB | -0.597 | 3.8e-50 |
| CSNK1E | 0.633 | 3.1e-58 | SQRDL | -0.583 | 2.7e-47 |
| MARCKSL1 | 0.592 | 4.4e-49 | TMBIM1 | -0.537 | 4.1e-39 |
| SOX4 | 0.580 | 7.1e-47 | IL15 | -0.535 | 7.1e-39 |
| NOTCH1 | 0.574 | 1.0e-45 | RAB32 | -0.528 | 1.0e-37 |
| MAP2 | 0.564 | 9.4e-44 | ANXA4 | -0.524 | 5.1e-37 |
| SOX11 | 0.557 | 1.1e-42 | S100A4 | -0.523 | 5.7e-37 |
| DLL3 | 0.549 | 3.8e-41 | FCGR2B | -0.522 | 1.0e-36 |
| PODXL2 | 0.545 | 1.3e-40 | RRAS | -0.518 | 4.4e-36 |
| MMP16 | 0.539 | 1.4e-39 | P4HA2 | -0.513 | 2.2e-35 |
| FXYD6 | 0.535 | 6.9e-39 | VAMP5 | -0.505 | 3.8e-34 |
| TOP2B | 0.532 | 1.8e-38 | NPC2 | -0.499 | 2.7e-33 |
| PHF16 | 0.532 | 2.2e-38 | CAST | -0.497 | 6.3e-33 |
| SEZ6L | 0.526 | 2.1e-37 | PLS3 | -0.497 | 4.7e-33 |
| BCAN | 0.524 | 4.0e-37 | COPZ2 | -0.495 | 1.1e-32 |
| CRMP1 | 0.519 | 3.1e-36 | PLAUR | -0.495 | 9.4e-33 |
| NLGN3 | 0.518 | 4.2e-36 | CLEC2B | -0.490 | 5.4e-32 |
| WDR6 | 0.511 | 3.9e-35 | LGALS3 | -0.477 | 3.9e-30 |
| PHLPP1 | 0.500 | 1.8e-33 | LY96 | -0.476 | 5.6e-30 |
| MTSS1 | 0.494 | 1.5e-32 | CLIC1 | -0.475 | 6.1e-30 |
| OLIG2 | 0.494 | 1.6e-32 | PIGP | -0.473 | 1.1e-29 |
| NRXN2 | 0.488 | 1.2e-31 | ALOX5 | -0.466 | 1.0e-28 |
| PAFAH1B3 | 0.488 | 1.2e-31 | TNFAIP8 | -0.465 | 1.3e-28 |
| DBN1 | 0.484 | 4.1e-31 | CSTA | -0.461 | 4.3e-28 |
| MMP15 | 0.483 | 5.8e-31 | S100A11 | -0.461 | 5.0e-28 |
| FLRT1 | 0.479 | 1.8e-30 | CTSB | -0.453 | 4.9e-27 |
| DPF1 | 0.479 | 1.9e-30 | CASP4 | -0.453 | 4.5e-27 |
| ASCL1 | 0.479 | 1.7e-30 | ANXA2 | -0.447 | 2.9e-26 |
| CRB1 | 0.476 | 5.3e-30 | RAB27A | -0.442 | 1.1e-25 |
| DCX | 0.472 | 1.5e-29 | MGST2 | -0.440 | 1.9e-25 |
| SATB1 | 0.472 | 1.6e-29 | SP100 | -0.439 | 2.7e-25 |
| ZNF510 | 0.471 | 2.1e-29 | ARPC1B | -0.437 | 4.6e-25 |
| RUFY3 | 0.467 | 7.5e-29 | TLR2 | -0.437 | 4.4e-25 |
| GNG4 | 0.467 | 7.8e-29 | ASL | -0.433 | 1.6e-24 |
| MYT1 | 0.461 | 5.1e-28 | KYNU | -0.433 | 1.3e-24 |
| CASK | 0.451 | 9.9e-27 | PROCR | -0.433 | 1.7e-24 |
| CDK5R1 | 0.446 | 4.4e-26 | FHL2 | -0.433 | 1.4e-24 |
| VAX2 | 0.442 | 1.1e-25 | LGALS1 | -0.432 | 2.1e-24 |
| GSK3B | 0.436 | 5.9e-25 | TIMP1 | -0.432 | 1.8e-24 |
| NCAM1 | 0.430 | 3.7e-24 | PHF11 | -0.432 | 2.1e-24 |
| MAPT | 0.429 | 4.5e-24 | MAN1A1 | -0.425 | 1.3e-23 |
| CKB | 0.425 | 1.4e-23 | AMPD3 | -0.424 | 1.5e-23 |
| CBX1 | 0.425 | 1.3e-23 | POLD4 | -0.418 | 7.2e-23 |
| KIF21B | 0.425 | 1.3e-23 | CYBRD1 | -0.418 | 7.1e-23 |
| MYO10 | 0.424 | 1.6e-23 | CHI3L1 | -0.418 | 7.9e-23 |
| NOL4 | 0.423 | 2.4e-23 | IFI30 | -0.416 | 1.2e-22 |
| MPPED2 | 0.422 | 2.8e-23 | FCGR2A | -0.414 | 2.1e-22 |
| BCOR | 0.420 | 5.4e-23 | ACSL1 | -0.413 | 3.0e-22 |
| CSPG5 | 0.419 | 6.0e-23 | MAN2A1 | -0.413 | 2.7e-22 |
| CLASP2 | 0.414 | 2.3e-22 | SYPL1 | -0.412 | 3.7e-22 |
| HMGB3 | 0.406 | 1.5e-21 | IQGAP1 | -0.405 | 2.4e-21 |
| TMCC1 | 0.403 | 3.3e-21 | RAC2 | -0.403 | 3.6e-21 |
| NKX2-2 | 0.400 | 7.1e-21 | ICAM3 | -0.402 | 4.3e-21 |
| RALGPS1 | 0.400 | 7.1e-21 | MS4A4A | -0.401 | 6.6e-21 |
| SOX2 | 0.399 | 9.7e-21 | CRYZ | -0.401 | 6.2e-21 |
| GRIA2 | 0.399 | 1.0e-20 | ANXA1 | -0.400 | 8.2e-21 |
| TTYH1 | 0.397 | 1.4e-20 | PTGER4 | -0.396 | 2.1e-20 |
| ZNF184 | 0.397 | 1.5e-20 | LTBP2 | -0.396 | 2.2e-20 |
| SCN3A | 0.396 | 1.9e-20 | SLC16A3 | -0.395 | 2.4e-20 |
| KLRC3 | 0.394 | 3.2e-20 | NCF2 | -0.393 | 3.8e-20 |
| AMOTL2 | 0.391 | 6.6e-20 | TGFBI | -0.391 | 6.2e-20 |
| TAF5 | 0.389 | 1.0e-19 | MAFB | -0.390 | 7.6e-20 |
| DUSP26 | 0.383 | 3.8e-19 | RHOG | -0.388 | 1.4e-19 |
| RAP2A | 0.383 | 4.4e-19 | CTSC | -0.387 | 1.5e-19 |
| CDC7 | 0.380 | 8.1e-19 | SWAP70 | -0.386 | 2.2e-19 |
| SRGAP3 | 0.377 | 1.7e-18 | IGFBP6 | -0.383 | 4.1e-19 |
| WASF1 | 0.375 | 2.4e-18 | SERPINA1 | -0.382 | 5.3e-19 |
| ICK | 0.372 | 5.2e-18 | MFSD1 | -0.382 | 5.6e-19 |
| RAD21 | 0.371 | 6.4e-18 | ACPP | -0.381 | 6.1e-19 |
| GSTA4 | 0.368 | 1.1e-17 | TNFAIP3 | -0.380 | 8.9e-19 |
| SEC61A2 | 0.367 | 1.5e-17 | IL1R1 | -0.380 | 8.3e-19 |
| EPHB1 | 0.364 | 2.8e-17 | SYNGR2 | -0.377 | 1.6e-18 |
| DPYSL4 | 0.363 | 3.3e-17 | CASP8 | -0.376 | 1.9e-18 |
| NRXN1 | 0.360 | 6.5e-17 | C5AR1 | -0.375 | 2.4e-18 |
| PDGRA | 0.352 | 3.6e-16 | CTSZ | -0.375 | 2.6e-18 |
| ERBB3 | 0.352 | 3.8e-16 | ARHGAP29 | -0.369 | 9.6e-18 |
| ABAT | 0.350 | 5.3e-16 | SHC1 | -0.366 | 1.8e-17 |
| GADD45G | 0.345 | 1.4e-15 | SERPINE1 | -0.366 | 1.7e-17 |
| CDC25A | 0.341 | 3.7e-15 | MSR1 | -0.366 | 1.9e-17 |
| ATP1A3 | 0.338 | 5.8e-15 | FXYD5 | -0.365 | 2.2e-17 |
| YPEL1 | 0.336 | 9.6e-15 | THBD | -0.364 | 2.8e-17 |
| FBXO21 | 0.335 | 1.1e-14 | LAIR1 | -0.363 | 3.6e-17 |
| ARHGEF9 | 0.335 | 1.1e-14 | CD14 | -0.359 | 8.9e-17 |
| HDAC2 | 0.331 | 2.2e-14 | GRN | -0.358 | 1.1e-16 |
| ZNF248 | 0.328 | 4.3e-14 | PTPRC | -0.354 | 2.6e-16 |
| FHOD3 | 0.324 | 8.5e-14 | LY75 | -0.353 | 3.1e-16 |
| HOXD3 | 0.320 | 1.9e-13 | GNA15 | -0.350 | 5.6e-16 |
| TSAPN3 | 0.318 | 2.8e-13 | VDR | -0.349 | 7.1e-16 |
| TOPBP1 | 0.318 | 3.0e-13 | CASP1 | -0.349 | 6.3e-16 |
| EPB41L5 | 0.317 | 3.1e-13 | ITGB2 | -0.346 | 1.4e-15 |
| BEX1 | 0.316 | 3.9e-13 | PTPN22 | -0.345 | 1.7e-15 |
| DGKI | 0.314 | 5.7e-13 | EMP3 | -0.345 | 1.7e-15 |
| STMN1 | 0.314 | 6.1e-13 | TCIRG1 | -0.344 | 1.8e-15 |
| CA10 | 0.308 | 1.7e-12 | SLAMF8 | -0.344 | 2.0e-15 |
| MCM10 | 0.307 | 1.9e-12 | SIGLEC7 | -0.344 | 1.7e-15 |
| P2RX7 | 0.305 | 3.0e-12 | ITGAM | -0.338 | 5.7e-15 |
| PDE10A | 0.295 | 1.6e-11 | SCPEP1 | -0.336 | 8.8e-15 |
| FGF9 | 0.293 | 2.2e-11 | TGFBR2 | -0.333 | 1.5e-14 |
| RAB33A | 0.293 | 2.1e-11 | STAT6 | -0.333 | 1.6e-14 |
| TMEM35 | 0.290 | 3.6e-11 | LILRB2 | -0.332 | 2.1e-14 |
| GRID2 | 0.290 | 3.6e-11 | SIGLEC9 | -0.330 | 3.0e-14 |
| PPM1D | 0.288 | 4.8e-11 | PLAU | -0.324 | 8.6e-14 |
| PAK7 | 0.286 | 6.6e-11 | ARSJ | -0.324 | 9.5e-14 |
| NANOG | 0.284 | 1.0e-10 | SEC24D | -0.323 | 1.1e-13 |
| PPM1E | 0.280 | 1.8e-10 | TRIM38 | -0.319 | 2.3e-13 |
| MAST1 | 0.279 | 2.2e-10 | ELF4 | -0.318 | 2.7e-13 |
a All the genes belong to either the proneural or mesenchymal signatures as described by Verhaak et al. [7].
b Correlations were analyzed by Pearson's χ2 test through the R2 platform (http://r2.amc.nl). For more correlations between PATZ1 and the mesenchymal signature see Supplementary Table 5.