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. 2017 Jul 26;8(35):59301–59311. doi: 10.18632/oncotarget.19573

Figure 1.

Figure 1

The mRNA (A) expression of DNMT1 in lung cancer tissues and corresponding paracancerous tissues were determined by Q-PCR. The mRNA (B) and protein (C) expression of DNMT1 in lung cancer cell lines A549 and H358 or normal lung epithelial cells BEAS-2B were determined by Q-PCR and WB. A549 and H358 cells were treated with 3 μM 5-Aza-CR and then the mRNA expression (D-E) and protein expression of RASSF1A and APC (F), and its methylation status (G-H) in lung cancer cell lines A549 and H358 or normal lung epithelial cells BEAS-2B were determined by MSP, Q-PCR and WB.*P< 0.05, **P< 0.01, ***P< 0.001, data represent the means ± s.d.