Table 2. Sex-specific association of individual SNPs with CAD.

SNP	Chr	Allele A#/B	Gene	Minor allele frequency, %
				Men									Women
				HWE	Cases	Controls	OR	95%	CI	p	HWE	Case	Control	OR	95%	CI	p
rs3742003	12	G/A	SH2B3	0.75	0.12	0.09	1.36	0.95	1.95	0.090	1.00	0.09	0.09	0.97	0.61	1.55	0.903
rs12580300	12	A/G	SH2B3	0.46	0.41	0.42	0.98	0.78	1.22	0.831	0.72	0.37	0.42	0.81	0.61	1.07	0.134
rs7309325	12	G/T	SH2B3	0.50	0.11	0.08	1.38	0.96	1.98	0.082	0.15	0.09	0.09	0.98	0.61	1.59	0.946
rs2078863	12	T/C	SH2B3	0.76	0.53	0.50	1.11	0.90	1.38	0.324	0.91	0.55	0.49	1.25	0.95	1.63	0.107
rs7296313	12	T/C	SH2B3	0.34	0.11	0.09	1.29	0.90	1.85	0.172	0.49	0.09	0.09	0.99	0.62	1.58	0.969
rs11879293	19	A/G	SMARCA4	0.70	0.22	0.27	0.76	0.59	0.98	0.036*	0.17	0.27	0.26	1.08	0.79	1.46	0.634
rs12232780	19	A/G	SMARCA4	0.78	0.18	0.25	0.64	0.49	0.84	0.001*	0.14	0.23	0.19	1.23	0.88	1.70	0.220
rs2072382	19	T/C	SMARCA4	0.03ψ	0.34	0.28	1.30	1.03	1.65	0.026*	0.19	0.31	0.28	1.15	0.86	1.55	0.343
rs1529729	19	C/T	SMARCA4	0.66	0.22	0.22	0.98	0.76	1.28	0.904	0.14	0.22	0.23	0.93	0.67	1.28	0.638
rs1122608	19	T/G	SMARCA4	0.41	0.08	0.10	0.74	0.51	1.08	0.120	1.00	0.09	0.08	1.22	0.76	1.96	0.411

SNP = single nucleotide polymorphism; CAD = coronary artery disease; OR = odds ratio;

95% CI = 95% confidence interval; Chr = chromosome; HWE = Hardy–Weinberg equilibrium

^#Minor allele

p values were calculated from two-sided chi-square tests for either allele frequency

^ψSite with HWE P < 0.05 is excluded in the men population

* p < 0.05 indicates statistical significance