Table 3. Genotypes of SH2B3 and SMARCA4 polymorphisms and CAD risk associations (age-adjusted).
| Men | Women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Model | Genotype | Control | Case | OR (95% CI) | p | Control | Case | OR (95% CI) | p |
| rs3742003 | Codominant | A/A | 319 (83.1%) | 224 (77%) | 1 | 0.076 | 246 (82%) | 136 (82.4%) | 1 | 0.960 |
| G/A | 63 (16.4%) | 67 (23%) | 1.57 (1.01-2.42) | 52 (17.3%) | 28 (17%) | 0.99 (0.53-1.85) | ||||
| G/G | 2 (0.5%) | 0 (0%) | 0.00 (0.00-NA) | 2 (0.7%) | 1 (0.6%) | 0.59 (0.02-20.73) | ||||
| Dominant | A/A | 319 (83.1%) | 224 (77%) | 1 | 0.054 | 246 (82%) | 136 (82.4%) | 1 | 0.950 | |
| G/A-G/G | 65 (16.9%) | 67 (23%) | 1.53 (0.99-2.36) | 54 (18%) | 29 (17.6%) | 0.98 (0.53-1.81) | ||||
| Recessive | A/A-G/A | 382 (99.5%) | 291 (100%) | 1 | 0.300 | 298 (99.3%) | 164 (99.4%) | 1 | 0.770 | |
| G/G | 2 (0.5%) | 0 (0%) | 0.00 (0.00-NA) | 2 (0.7%) | 1 (0.6%) | 0.59 (0.02-20.72) | ||||
| Overdominant | A/A-G/G | 321 (83.6%) | 224 (77%) | 1 | 0.041* | 248 (82.7%) | 137 (83%) | 1 | 0.990 | |
| G/A | 63 (16.4%) | 67 (23%) | 1.57 (1.02-2.43) | 52 (17.3%) | 28 (17%) | 0.99 (0.53-1.85) | ||||
| Log-additive | --- | --- | --- | 1.47 (0.96-2.23) | 0.074 | --- | --- | 0.97 (0.53-1.75) | 0.910 | |
| rs12580300 | Codominant | G/G | 134 (35%) | 98 (33.7%) | 1 | 0.820 | 99 (33%) | 63 (38.2%) | 1 | 0.043* |
| G/A | 179 (46.7%) | 147 (50.5%) | 1.08 (0.73-1.59) | 150 (50%) | 82 (49.7%) | 0.66 (0.39-1.13) | ||||
| A/A | 70 (18.3%) | 46 (15.8%) | 0.93 (0.56-1.55) | 51 (17%) | 20 (12.1%) | 0.39 (0.18-0.85) | ||||
| Dominant | G/G | 134 (35%) | 98 (33.7%) | 1 | 0.840 | 99 (33%) | 63 (38.2%) | 1 | 0.039* | |
| G/A-A/A | 249 (65%) | 193 (66.3%) | 1.04 (0.72-1.49) | 201 (67%) | 102 (61.8%) | 0.59 (0.35-0.97) | ||||
| Recessive | G/G-G/A | 313 (81.7%) | 245 (84.2%) | 1 | 0.610 | 249 (83%) | 145 (87.9%) | 1 | 0.046 | |
| A/A | 70 (18.3%) | 46 (15.8%) | 0.89 (0.56-1.41) | 51 (17%) | 20 (12.1%) | 0.50 (0.24-1.00) | ||||
| Overdominant | G/G-A/A | 204 (53.3%) | 144 (49.5%) | 1 | 0.570 | 150 (50%) | 83 (50.3%) | 1 | 0.590 | |
| G/A | 179 (46.7%) | 147 (50.5%) | 1.11 (0.78-1.56) | 150 (50%) | 82 (49.7%) | 0.87 (0.54-1.42) | ||||
| Log-additive | --- | --- | --- | 0.98 (0.77-1.26) | 0.890 | --- | --- | 0.63 (0.44-0.91) | 0.012* | |
| rs7309325 | Codominant | T/T | 320 (83.5%) | 226 (77.7%) | 1 | 0.100 | 248 (82.7%) | 137 (83.5%) | 1 | 0.880 |
| G/T | 62 (16.2%) | 65 (22.3%) | 1.55 (1.00-2.40) | 52 (17.3%) | 26 (15.8%) | 1.02 (0.54-1.92) | ||||
| G/G | 1 (0.3%) | 0 (0%) | 0.00 (0.00-NA) | 0 (0%) | 1 (0.6%) | NA (0.00-NA) | ||||
| Dominant | T/T | 320 (83.5%) | 226 (77.7%) | 1 | 0.055 | 248 (82.7%) | 137 (83.5%) | 1 | 0.930 | |
| G/T-G/G | 63 (16.4%) | 65 (22.3%) | 1.53 (0.99-2.37) | 52 (17.3%) | 27 (16.5%) | 1.03 (0.55-1.93) | ||||
| Recessive | T/T-G/T | 382 (99.7%) | 291 (100%) | 1 | 0.420 | 300 (100%) | 163 (99.4%) | 1 | 0.620 | |
| G/G | 1 (0.3%) | 0 (0%) | 0.00 (0.00-NA) | 0 (0%) | 1 (0.6%) | NA (0.00-NA) | ||||
| Overdominant | T/T-G/G | 321 (83.8%) | 226 (77.7%) | 1 | 0.047* | 248 (82.7%) | 138 (84.2%) | 1 | 0.960 | |
| G/T | 62 (16.2%) | 65 (22.3%) | 1.56 (1.01-2.41) | 52 (17.3%) | 26 (15.8%) | 1.02 (0.54-1.91) | ||||
| Log-additive | --- | --- | --- | 1.49 (0.97-2.29) | 0.066 | --- | --- | 1.04 (0.56-1.94) | 0.900 | |
| T/T | 94 (24.4%) | 78 (26.8%) | 1 | 72 (24%) | 44 (26.7%) | 1 | 0.022* | |||
| Codominant | C/T | 196 (50.9%) | 150 (51.5%) | 0.80 (0.53-1.21) | 0.480 | 152 (50.7%) | 93 (56.4%) | 0.82 (0.46-1.47) | ||
| C/C | 95 (24.7%) | 63 (21.6%) | 0.76 (0.46-1.25) | 76 (25.3%) | 28 (17%) | 0.39 (0.19-0.81) | ||||
| Dominant | T/T | 94 (24.4%) | 78 (26.8%) | 1 | 0.240 | 72 (24%) | 44 (26.7%) | 1 | 0.140 | |
| C/T-C/C | 291 (75.6%) | 213 (73.2%) | 0.79 (0.53-1.17) | 228 (76%) | 121 (73.3%) | 0.66 (0.38-1.15) | ||||
| Recessive | T/T-C/T | 290 (75.3%) | 228 (78.3%) | 1 | 0.560 | 224 (74.7%) | 137 (83%) | 1 | 0.007* | |
| rs2078863 | C/C | 95 (24.7%) | 63 (21.6%) | 0.89 (0.59-1.34) | 76 (25.3%) | 28 (17%) | 0.44 (0.24-0.82) | |||
| Overdominant | T/T-C/C | 189 (49.1%) | 141 (48.5%) | 1 | 0.580 | 148 (49.3%) | 72 (43.6%) | 1 | 0.330 | |
| C/T | 196 (50.9%) | 150 (51.5%) | 0.91 (0.64-1.28) | 152 (50.7%) | 93 (56.4%) | 1.27 (0.78-2.06) | ||||
| Log-additive | --- | --- | --- | 0.87 (0.68-1.12) | 0.270 | --- | --- | 0.64 (0.44-0.91) | 0.012* | |
| rs11879293 | G/G | 205 (53.5%) | 176 (60.5%) | 1 | 0.018* | 160 (53.3%) | 86 (52.1%) | 1 | 0.760 | |
| Codominant | G/A | 148 (38.6%) | 101 (34.7%) | 0.68 (0.47-0.99) | 125 (41.7%) | 68 (41.2%) | 0.83 (0.50-1.37) | |||
| A/A | 30 (7.8%) | 14 (4.8%) | 0.41 (0.19-0.89) | 15 (5%) | 11 (6.7%) | 0.93 (0.35-2.46) | ||||
| Dominant | G/G | 205 (53.5%) | 176 (60.5%) | 1 | 0.012* | 160 (53.3%) | 86 (52.1%) | 1 | 0.490 | |
| G/A-A/A | 178 (46.5%) | 115 (39.5%) | 0.64 (0.45-0.91) | 140 (46.7%) | 79 (47.9%) | 0.84 (0.52-1.37) | ||||
| Recessive | G/G-G/A | 353 (92.2%) | 277 (95.2%) | 1 | 0.049* | 285 (95%) | 154 (93.3%) | 1 | 0.990 | |
| A/A | 30 (7.8%) | 14 (4.8%) | 0.48 (0.23-1.02) | 15 (5%) | 11 (6.7%) | 1.01 (0.39-2.60) | ||||
| Overdominant | G/G-A/A | 235 (61.4%) | 190 (65.3%) | 1 | 0.110 | 175 (58.3%) | 97 (58.8%) | 1 | 0.470 | |
| G/A | 148 (38.6%) | 101 (34.7%) | 0.75 (0.52-1.07) | 125 (41.7%) | 68 (41.2%) | 0.84 (0.51-1.37) | ||||
| Log-additive | --- | --- | --- | 0.66 (0.50-0.89) | 0.005* | --- | --- | 0.90 (0.61-1.32) | 0.580 | |
| rs12232780 | Codominant | G/G | 215 (56.1%) | 198 (68%) | 1 | 0.002* | 0.970 | |||
| G/A | 146 (38.1%) | 84 (28.9%) | 0.56 (0.39-0.82) | 191 (63.7%) | 94 (57%) | 1 | ||||
| A/A | 22 (5.7%) | 9 (3.1%) | 0.33 (0.13-0.84) | 102 (34%) | 67 (40.6%) | 1.03 (0.62-1.71) | ||||
| Dominant | G/G | 215 (56.1%) | 198 (68%) | 1 | 0.001* | 7 (2.3%) | 4 (2.4%) | 0.86 (0.19-4.01) | 0.930 | |
| G/A-A/A | 168 (43.9%) | 93 (32%) | 0.53 (0.37-0.76) | 191 (63.7%) | 94 (57%) | 1 | ||||
| Recessive | G/G-G/A | 361 (94.3%) | 282 (96.9%) | 1 | 0.047* | 109 (36.3%) | 71 (43%) | 1.02 (0.62-1.68) | 0.840 | |
| A/A | 22 (5.7%) | 9 (3.1%) | 0.41 (0.16-1.03) | 293 (97.7%) | 161 (97.6%) | 1 | ||||
| Overdominant | G/G-A/A | 237 (61.9%) | 207 (71.1%) | 1 | 0.007* | 7 (2.3%) | 4 (2.4%) | 0.85 (0.19-3.92) | 0.880 | |
| G/A | 146 (38.1%) | 84 (28.9%) | 0.60 (0.42-0.88) | 198 (66%) | 98 (59.4%) | 1 | ||||
| Log-additive | --- | --- | --- | 0.57 (0.41-0.78) | 0.000* | 102 (34%) | 67 (40.6%) | 1.04 (0.63-1.72) | ||
| Codominant | C/C | 188 (49.5%) | 129 (44.3%) | 1 | 0.013* | 152 (50.7%) | 78 (47.3%) | 1 | 0.670 | |
| T/C | 171 (45%) | 128 (44%) | 1.05 (0.73-1.52) | 130 (43.3%) | 73 (44.2%) | 1.15 (0.69-1.90) | ||||
| T/T | 21 (5.5%) | 34 (11.7%) | 2.69 (1.36-5.32) | 18 (6%) | 14 (8.5%) | 1.47 (0.59-3.66) | ||||
| rs2072382 | Dominant | C/C | 188 (49.5%) | 129 (44.3%) | 1 | 0.270 | 152 (50.7%) | 78 (47.3%) | 1 | 0.470 |
| T/C-T/T | 192 (50.5%) | 162 (55.7%) | 1.21 (0.86-1.72) | 148 (49.3%) | 87 (52.7%) | 1.20 (0.74-1.94) | ||||
| Recessive | C/C-T/C | 359 (94.5%) | 257 (88.3%) | 1 | 0.003 | 282 (94%) | 151 (91.5%) | 1 | 0.470 | |
| T/T | 21 (5.5%) | 34 (11.7%) | 2.62 (1.36-5.06) | 18 (6%) | 14 (8.5%) | 1.38 (0.57-3.32) | ||||
| Overdominant | C/C-T/T | 209 (55%) | 163 (56%) | 1 | 0.620 | 170 (56.7%) | 92 (55.8%) | 1 | 0.740 | |
| T/C | 171 (45%) | 128 (44%) | 0.91 (0.65-1.30) | 130 (43.3%) | 73 (44.2%) | 1.09 (0.67-1.77) | ||||
| Log-additive | --- | --- | --- | 1.35 (1.02-1.77) | 0.034 | --- | --- | 1.19 (0.81-1.73) | 0.380 | |
OR = odds ratio; 95 % CI = 95 % confidence interval
p values were calculated by unconditional logistic regression adjusted for age
*p < 0.05 indicates statistical significance