Table 4A. Functional analysis of 636 differentially expressed genes (DEGs) between Normal vs. HCV+ tissue samples.
| Top Canonical Pathways | ||
|---|---|---|
| Name | p-value | ratio |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 4.25E-04 | 28/127 (0.22) |
| Antigen Presentation Pathway | 4.34E-04 | 8/18 (0.44) |
| Graft-versus-Host Disease Signaling | 1.48E-03 | 8/21 (0.381) |
| Inhibition of Matrix Metalloproteases | 2.89E-03 | 8/23 (0.348) |
| T Helper Cell Differentiation | 3.37E-03 | 11/39 (0.282) |
| Top Toxicity Functions | ||
| Name | p-value | # Molecules |
| Liver Cirrhosis | 4.96E-03 – 4.96E-03 | 5 |
| Liver Necrosis/Cell Death | 1.01E-01 – 1.01E-01 | 4 |
| Liver Adhesion | 1.14E-01 – 1.14E-01 | 1 |
| Liver Fibrosis | 2.16E-01 – 6.22E-01 | 3 |
| Liver Proliferation | 2.16E-01 – 6.22E-01 | 3 |
| Molecular and Cellular Functions | ||
| Name | p-value | # Molecules |
| DNA Replication, Recombination, and Repair | 2.29E-02 – 2.29E-02 | 3 |