Table 4B. Functional analysis of 61 differentially expressed genes (DEGs) between HCCN vs. HCC tissue samples.
| Top Canonical Pathways | ||
|---|---|---|
| Name | p-value | ratio |
| GADD45 Signaling | 2.93E-06 | 8/19 (0.421) |
| Cell Cycle Control of Chromosomal Replication | 1.07E-05 | 8/22 (0.364) |
| Estrogen-mediated S-Phase Entry | 2.24E-05 | 8/24 (0.333) |
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 2.31E-05 | 11/46 (0.239) |
| Cyclins and Cell Cycle Regulation | 6.44E-05 | 13/69 (0.188) |
| Top Toxicity Functions | ||
| Name | p-value | # Molecules |
| Hepatocellular Carcinoma | 3.50E-03 – 5.87E-01 | 9 |
| Liver Hyperplasia/Hyperproliferation | 3.50E-03 – 5.87E-01 | 31 |
| Glutathione Depletion in Liver | 5.37E-02 – 5.38E-01 | 2 |
| Liver Damage | 5.37E-02 – 3.92E-01 | 7 |
| Liver Degradation | 5.37E-02 – 5.37E-02 | 1 |
| Molecular and Cellular Functions | ||
| Name | p-value | # Molecules |
| Carbohydrate Metabolism | 1.42E-03 – 1.42E-03 | 3 |
| Drug Metabolism | 1.42E-03 – 1.42E-03 | 3 |
| Molecular Transport | 1.42E-03 – 3.73E-02 | 7 |
| Small Molecule Biochemistry | 1.42E-03 – 3.73E-02 | 10 |
| Post-Translational Modification | 2.88E-03 – 2.88E-03 | 2 |
Target validation of gene expression and splice variants in Caucasian and African Americans tissue samples