Table 2. Correlation of EMT-TFs overexpression and clinicopathological features in HCC.
| variable | No.of | No.of | OR (95% CI) | P | Heterogeneity | Model used | |
|---|---|---|---|---|---|---|---|
| studies | patients | I2 (%) | Ph | ||||
| TNM stage (III+IV vs. I+II) | 6 | 766 | 2.18 (1.08–4.38) | 0.03 | 76 | 0.0008 | random |
| Differentiation (poor vs. well+ moderate) | 5 | 435 | 1.96 (1.22–3.17) | 0.006 | 0 | 0.58 | fixed |
| Intrahepatic metastasis (pos vs. neg) | 3 | 258 | 2.94 (1.56–5.54) | 0.0009 | 0 | 0.86 | fixed |
| Vascular invasion (pos vs. neg) | 2 | 218 | 3.09 (1.67–5.73) | 0.0003 | 0 | 0.98 | fixed |
| Age (> 55 vs. ≤ 55) | 2 | 219 | 1.27 (0.71–2.26) | 0.42 | 48 | 0.16 | fixed |
| Gender (male vs. female) | 7 | 817 | 1.32 (0.89–1.96) | 0.17 | 0 | 0.80 | fixed |
| Tumor size (> 5 cm vs. ≤ 5 cm) | 6 | 687 | 1.09 (0.62–1.91) | 0.76 | 63 | 0.02 | random |
| Cirrhosis (yes vs. no) | 3 | 458 | 0.83 (0.55–1.25) | 0.38 | 50 | 0.13 | fixed |
| HBSAg (pos vs. neg) | 4 | 498 | 1.30 (0.75–2.26) | 0.35 | 0 | 0.89 | fixed |
| AFP (> 20 ng/ml vs. ≤ 20 ng/ml ) | 4 | 483 | 0.90 (0.42–1.96) | 0.80 | 68 | 0.02 | random |
Abbreviations: HBSAg = hepatitis B surface antigen; AFP = alpha fetoprotein; pos = positive; neg = negative.