Table 2. Treatment-Related AEs (Grade 1-4/3-4) for PD-1/PD-L1 antibodies vs. docetaxel.
| AEs (Grade 1–4/3-4) | PD1/PD-L1antibody | DOX | Heterogeneity P and I2 | RR (95%CI) | Z value | P value | |
|---|---|---|---|---|---|---|---|
| any events(G1-4) | 1201/1851 | 1464/1728 | 0.421 | 0.0% | 0.77(0.74,0.79) | 13.38 | 0.000 |
| (G3-4) | 284/1851 | 751/1728 | 0.000 | 91.0% | 0.33(0.22,0.51) | 5.03 | 0.000 |
| Nausea(G1-4) | 239/1851 | 358/1728 | 0.047 | 55.0% | 0.58(0.46,0.75) | 4.28 | 0.000 |
| (G3-4) | 10/1851 | 8/1728 | 0.827 | 0.0% | 0.15(0.48,2.77) | 0.31 | 0.756 |
| Febrile neutropenia(G1-4) | 1/1851 | 146/1728 | 0.994 | 0.0% | 0.02(0.01,0.06) | 7.06 | 0.000 |
| (G3-4) | 1/1851 | 144/1728 | 0.994 | 0.0% | 0.02(0.01,0.07) | 7.03 | 0.000 |
| Diarrhea(G1-4) | 182/1851 | 371/1728 | 0.032 | 59.0% | 0.41(0.31,0.55) | 5.98 | 0.000 |
| (G3-4) | 9/1851 | 35/1728 | 0.800 | 0.0% | 0.26(0.13,0.52) | 3.79 | 0.000 |
| Neutropenia(G1-4) | 16/1851 | 322/1728 | 0.051 | 55.0% | 0.04(0.02,0.10) | 6.74 | 0.000 |
| (G3-4) | 3/1851 | 246/1728 | 0.684 | 0.0% | 0.02(0.01,0.05) | 9.04 | 0.000 |
| Anemia(G1-4) | 110/1851 | 319/1728 | 0.001 | 77.0% | 0.25(0.14,0.42) | 5.01 | 0.000 |
| (G3-4) | 19/1709 | 54/1593 | 0.658 | 0.0% | 0.34(0.20,0.56) | 4.17 | 0.000 |
| Fatigue(G1-4) | 354/1851 | 524/1728 | 0.225 | 28.0% | 0.63(0.56,0.71) | 7.65 | 0.000 |
| (G3-4) | 32/1851 | 72/1728 | 0.281 | 20.0% | 0.42(0.28,0.63) | 4.17 | 0.000 |
| Rash(G1-4) | 105/1100 | 44/1015 | 0.070 | 57.0% | 2.01(1.14,3.51) | 2.43 | 0.020 |
| (G3-4) | 3/1100 | 2/1015 | 0.540 | 0.0% | 1.17(0.31,4.42) | 0.24 | 0.810 |
| Alopecia(G1-4) | 11/1851 | 551/1728 | 0.900 | 0.0% | 0.02(0.01,0.04) | 13.31 | 0.000- |
| (G3-4) | 0/1851 | 7/1728 | 0.997 | 0.0% | 0.25 (0.06,0.99) | 1.98 | 0.048 |
| Colitis(G1-4) | 11/1242 | 0/1150 | 0.999 | 0.0% | 4.99 (1.45,17.11) | 2.55 | 0.011 |
| (G3-4) | 7/1242 | 0/1150 | 0.994 | 0.0% | 3.55 (0.88,14.28) | 1.78 | 0.075 |
| Hypothyroidism(G1-4) | 87/1242 | 2/1150 | 0.974 | 0.0% | 23.36(8.04-67.90) | 5.79 | 0.000 |
| Hyperthyroidism(G1-4) | 36/969 | 6/886 | 0.765 | 0.0% | 5.10(2.23-11.68) | 3.85 | 0.000 |
| Pneumonitis(G1-4) | 62/1242 | 18/1150 | 0.653 | 0.0% | 3.19(1.90-5.34) | 4.40 | 0.000 |
| interstitial lung disease(G1-4) | 5/1100 | 5/1015 | 0.607 | 0.0% | 0.93(0.29-2.87) | 0.13 | 0.893 |