Table 2. Summary ORs and 95% CIs of HOTAIR rs4759314 polymorphism and cancer risk.
| Locus | N* | Allele (G vs. A) | Recessive (GG vs. GA+AA) | Dominant (GA+GG vs. AA) | Homozygote (GG vs. AA) | Heterozygote (GA vs. AA) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | ||
| Total | 12 | 1.11 (0.99–1.26) 0.087 |
50.4 | 1.11 (0.80–1.55) 0.532 |
0 | 1.11 (1.01–1.21) 0.026 |
44.4 | 1.31 (0.95–1.80) 0.096 |
0 | 1.09 (1.00–1.20) 0.058 |
38.1 |
| Source of controls | |||||||||||
| Population | 4 | 1.00 (0.84–1.19) 0.962 |
0 | 0.93 (0.29–3.00) 0.898 |
0 | 1.00 (0.83–1.20) 0.977 |
0 | 0.93 (0.29–2.99) 0.901 |
0 | 1.00 (0.83–1.20) 0.990 |
0 |
| Hospital | 6 | 1.13 (0.92–1.38) 0.259 |
68.7 | 0.96 (0.60–1.53) 0.862 |
17.2 | 1.13 (0.91–1.41) 0.256 |
67.3 | 1.07 (0.68–1.67) 0.782 |
25.1 | 1.13 (0.91–1.40) 0.273 |
65.4 |
| Method | |||||||||||
| RFLP | 5 | 1.04 (0.89–1.22) 0.629 |
0 | 0.89 (0.32–2.45) 0.817 |
0 | 1.04 (0.89–1.23) 0.604 |
0 | 0.95 (0.35–2.60) 0.925 |
0 | 1.05 (0.89–1.24) 0.589 |
0 |
| Taqman | 4 | 1.15 (0.83–1.61) 0.403 |
81.1 | 0.59 (0.28–1.28) 0.184 | 34.6 | 1.18 (0.83–1.66) 0.356 | 80.2 | 0.69 (0.33–1.45) 0.325 |
48.4 | 1.19 (0.85–1.66) 0.317 |
78.5 |
| MALDI-TOF-MS | 3 | 1.21 (1.05–1.39) 0.009 |
0 | 1.39 (0.92–2.09) 0.116 |
0 | 1.17 (1.00–1.36) 0.055 |
0 | 1.64 (1.12–2.41) 0.012 |
0 | 1.10 (0.93–1.30) 0.264 |
0 |
| Type of cancer | |||||||||||
| Estrogen-dependent | 3 | 1.18 (1.02–1.37) 0.022 |
42.2 | 1.36 (0.86–2.14) 0.192 | 0 | 1.15 (0.98–1.35) 0.091 |
4.7 | 1.66 (1.08–2.55) 0.022 |
0 | 1.09 (0.92–1.30) 0.303 |
0 |
| Gastrointestinal | 5 | 1.09 (0.90–1.33) 0.369 |
64.3 | 0.69 (0.35–1.34) 0.270 | 0 | 1.11 (0.90–1.36) 0.326 |
63.5 | 0.77 (0.41–1.48) 0.437 |
5.3 | 1.11 (0.91–1.36) 0.295 |
61.7 |
| Age and sex matched | 11 | 1.12 (0.98–1.28) 0.099 |
54.8 | 1.11 (0.79–1.56) 0.540 |
0 | 1.11 (1.01–1.22) 0.027 |
49.4 | 1.31 (0.95–1.81) 0.098 |
0 | 1.10 (1.00–1.21) 0.060 |
43.7 |
| Controls in HWE | 10 | 1.09 (0.95–1.26) 0.237 |
51.8 | 0.84 (0.51–1.38) 0.493 |
0 | 1.10 (0.95–1.28) 0.200 |
50.4 | 0.94 (0.58–1.53) 0.815 |
0 | 1.09 (0.99–1.21) 0.092 |
47.6 |
* Numbers of comparisons. RFLP: Restriction Fragment Length Polymorphism. MOLDI-TOF-MS: Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry. HWE: Hardy-Weinberg Equilibrium.