Table 3. Summary ORs and 95% CIs of HOTAIR rs7958904 polymorphism and cancer risk.
| Locus | N* | Allele (C vs. G) | Recessive (CC vs. CG+GG) | Dominant (CG+CC vs. GG) | Homozygote (CC vs. GG) | Heterozygote (CG vs. GG) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | OR (95%CI) P | I2(%) | ||
| Total | 6 | 0.82 (0.77–0.87) < 0.01 |
0 | 0.79 (0.67–0.93) < 0.01 |
0 | 0.81 (0.75–0.88)< 0.01 |
0 | 0.64 (0. 54–0.75) < 0.01 |
0 | 0.85 (0.78–0.93) < 0.01 |
0 |
| Method | |||||||||||
| Taqman | 3 | 0.85 (0.78–0.93) < 0.01 |
0 | 0.85 (0.69–1.06) 0.143 |
0 | 0.84 (0.76–0.94) < 0.01 |
0 | 0.72 (0.58–0.89) < 0.01 |
0 | 0.87 (0.78–0.98) 0.017 |
0 |
| MOLDI-TOF-MS | 3 | 0.77 (0.70–0.86) < 0.01 |
0 | 0.71 (0.54–0.91) < 0.01 |
0 | 0.78 (0.68–0.88) < 0.01 |
0 | 0.55 (0.42–0.70) < 0.01 |
0 | 0.83 (0.73–0.95) < 0.01 |
0 |
| Type of cancer | |||||||||||
| Estrogen-dependent | 1 | 0.77 (0.67–0.89) < 0.01 |
NA | 0.67 (0.47–0.98) 0.037 |
NA | 0.78 (0.65–0.93)< 0.01 |
NA | 0.53 (0.37–0.76) < 0.01 |
NA | 0.84 (0.70–1.01) 0.063 |
NA |
| Gastrointestinal | 3 | 0.85 (0.78–0.93) < 0.01 |
0 | 0.85 (0.69–1.06) 0.143 |
0 | 0.84 (0.76–0.94) < 0.01 |
0 | 0.72 (0.58–0.89) < 0.01 |
0 | 0.87 (0.78–0.98) 0.017 |
0 |
| Controls in HWE | 5 | 0.83 (0.77–0.89) < 0.01 |
0 | 0.79 (0.66–0.94) < 0.01 |
0 | 0.82 (0.75–0.90) < 0.01 |
0 | 0.65 (0.55–0.77) < 0.01 |
0 | 0.86 (0.78–0.94) < 0.01 |
0 |
* Numbers of comparisons. MOLDI-TOF-MS: Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry. HWE: Hardy-Weinberg Equilibrium. NA: not available.