Skip to main content
. 2017 May 31;8(35):59854–59866. doi: 10.18632/oncotarget.18322

Figure 4. DRPs decrease the formation of new liver metastases after liver I/R.

Figure 4

A. A schematic representation of the experimental design is depicted. Mice were subjected to liver I/R in order to induce surgical stress. Intrasplenic injection of MC38 colorectal cancer cell lines was performed at the same time. DRPs or control PEG intraperitoneally were given at the time of procedure. B. and C. After three weeks, I/R resulted in a significant increase in gross surface metastatic nodules compared with the sham groups (mean 12 nodules in I/R versus 4 nodules in sham; p < 0.001). Treatment with DRPs resulted in a significant decrease in the number of gross metastases compared to control treated mice (mean 12 nodules in I/R control versus 5 nodules in I/R DRP; p < 0.001).