Figure 6. Schematic diagram illustrating the proposed role of DRPs in decreasing injury and metastases after liver I/R.

A. DRPs alter the traffic of blood cells within microvessels. B. DRPs attenuate the acute inflammatory response, decrease the recruitment and activation of neutrophils and concurrent NET formation, decrease the formation of microthrombi and subsequently protect the liver from the resulting damage. C. DRPs have favorable oncological outcomes in mice subjected to surgical stress by decreasing both the formation of new metastatic disease and the growth of established micrometastases.