Table 4. Subgroup analyses of the association between high p-Akt expression and overall survival in the group “U+E” of patients with gastric cancer.
| Subgroup | Data sets | Model | HR (95%CI) | P | I2 | Ph |
|---|---|---|---|---|---|---|
| All | 11 | Random | 1.41 [1.01, 1.97] | 0.04 | 62% | 0.004 |
| Location | ||||||
| C | 5 | Random | 1.04 [0.51, 2.10] | 0.92 | 84% | <0.0001 |
| N | 1 | - | 1.10 [0.20, 6.05] | 0.91 | - | - |
| CN | 5 | Fixed | 1.76 [1.35, 2.30] | <0.0001 | 0% | 0.96 |
| Region | ||||||
| Asian | 10 | Random | 1.42 [1.00, 2.01] | 0.05 | 65% | 0.002 |
| Caucasian | 1 | - | 1.10 [0.20, 6.05] | 0.91 | - | - |
| Treatment | ||||||
| Surgical | 10 | Random | 1.42 [1.00, 2.01] | 0.05 | 65% | 0.002 |
| Non-surgical | 1 | - | 1.10 [0.20, 6.05] | 0.91 | - | - |
| Sample size | ||||||
| <100 | 3 | Fixed | 2.09 [1.12, 3.87] | 0.02 | 0% | 0.72 |
| ≧100 | 8 | Random | 1.28 [0.86, 1.91] | 0.22 | 72% | 0.0009 |
| Obtainment | ||||||
| univariate | 4 | Fixed | 1.88 [1.45, 2.43] | <0.00001 | 0% | 0.85 |
| estimate | 7 | Random | 1.13 [0.65, 1.95] | 0.67 | 73% | 0.001 |
| Scoring method | ||||||
| E | 7 | Random | 1.46 [0.96, 2.21] | 0.08 | 57% | 0.03 |
| EI | 4 | Random | 1.21 [0.60, 2.44] | 0.59 | 75% | 0.008 |
| Cut-off | ||||||
| 1% | 1 | - | 1.63 [0.64, 4.15] | 0.31 | - | - |
| 10% | 5 | Random | 1.19 [0.65, 2.18] | 0.57 | 64% | 0.03 |
| Moderate | 5 | Random | 1.51 [0.89, 2.56] | 0.13 | 73% | 0.005 |
| Measure method | ||||||
| IHC | 10 | Random | 1.35 [0.95, 1.92] | 0.10 | 64% | 0.003 |
| Immunoblot | 1 | - | 2.45 [0.94, 6.37] | 0.07 | - | - |
| Primary antibody | ||||||
| Rabbit | 4 | Random | 1.13 [0.45, 2.85] | 0.79 | 75% | 0.007 |
| Mouse | 3 | Fixed | 1.68 [1.17, 2.41] | 0.005 | 0 | 0.88 |
| pAb | 1 | - | 1.75 [1.12, 2.73] | 0.02 | - | - |
| mAb | 1 | - | 1.78 [1.09, 2.91] | 0.02 | - | - |
| NR | 2 | Random | 1.03 [0.20, 5.29] | 0.97 | 87% | 0.005 |
C: cytoplasm; N: nucleus; CN: cytoplasm and nucleus; U+E: univariate analysis + estimate of Kaplan–Meier survival curves.