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. 2017 Sep 15;7:11733. doi: 10.1038/s41598-017-09417-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KH176 maintains microstructural coherence in the brain of Ndufs4 ^−/− mice. (A) DTI was used to asses microstructural organization in the mouse brain. ROIs in gray and white matter are overlain on FA maps. CC, corpus callosum; Cereb, cerebral cortex; CP, cerebral peduncle, CPu, caudate putamen; HC, hippocampus; EC, external capsule. (B) FA values of control (white bar) and Ndufs4 ^−/− vehicle-treated (gray bar) mice (n = 5–7) (PD > 42). (C) FA values of Ndufs4 ^−/− vehicle (gray bar) and KH176-treated (black bar) mice (n = 6–7) (PD > 42). FA values expressed as mean ± SEM. Multivariate ANOVA (*p ≤ 0.05).