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. 2017 Jul;15(7):447–452.

Table I.

The protocol for induction of the chronic variable stress (CVS) in 15 days for the rat model

Stressor applied Days
Cold restraint (1.5 hr) 1
Inclination of home cages (3 hr) 2
Flashing light (1.5 hr) 3
Restraint (1.5 hr) 4
Isolation (24 hr) 5
Damp bedding (3 hr) 6
Inclination of home cages (2 hr) 7
No stressor applied 8
Flashing light (1.5 hr) 9
Isolation (24 hr) 10
Water deprivation (24 hr) 11
Restraint (2 hr) 12
Damp bedding (2 hr) 13
Cold restraint (2 hr) 14
Inclination of home cages (3 hr) 15