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. 2017 Sep 15;7:11670. doi: 10.1038/s41598-017-10549-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ADAM8 expression in human atherosclerotic lesions. (a) Microarray expression profiling of carotid atherosclerotic plaque macrophages and lung, liver and spleen macrophages (n = 4 patients per tissue, nonparametric Mann-Whitney U test). (b) Relative expression of ADAM8 mRNA in early, advanced stable and unstable human plaques. Values have been corrected for GAPDH expression (n = 5–6) and ADAM8 expression levels in early plaques were normalized to 1 (one way analysis of variance followed by Dunn’s multiple comparison test). (c,d) Immunohistochemical stainings for ADAM8 in human atherosclerotic lesions. (c) Representative images of a shoulder region (scale bar, 400 μm), a region rich in foamy macrophages (scale bar, 50 μm) and a negative control (d, scale bar, 200 μm) are shown.