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. 2017 Sep 15;7:11670. doi: 10.1038/s41598-017-10549-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Adam8 expression in leukocyte subsets and ADAM8 deficient BMDMs show reduced inflammatory response. (a) Relative Adam8 mRNA expression in sorted murine C57Bl/6 blood B-lymphocytes, T-lymphocytes, monocytes, neutrophils, resident peritoneal macrophages and BMDMs (n = 4 mice). Fold changes of Adam8/Gapdh expression is shown. (b) Adam8 expression in wildtype C57Bl/6 BMDMs exposed for 24 h to 0.25 μg/ml VLDL, LDL or oxLDL (n = 2 per group). (c) Western blot analysis of BMDMs stimulated with PBS or 0.25 μg/ml oxLDL (n = 3 per group). (d) Cytokine or nitric oxide (NO) secretion by Adam8 ^+/+ and Adam8 ^−/− BMDMs that were pre-treated with PBS or 0.25 μg/ml oxLDL for 24 hours, followed by a 6 hours (TNFα and IL-10) or 24 hours (IL-12 and NO) incubation with PBS or 10 ng/ml LPS (n = 3 mice per group, nonparametric Mann-Whitney U test).