Table 3.

Gene expression of HK1, PK, PDH, HK2, and GPR81 measured 7 days post-TBI.

Tissue	Drug	Treat	HK1	PK	PDH	HK2	GPR-81
Contralateral cortex	Vehicle	Sham	1.40 ± 0.06	4.96 ± 0.18	4.75 ± 0.37	8.2 ± 0.81	10.31 ± 1.32
		TBI	1.32 ± 0.05	5.04 ± 0.22	4.62 ± 0.26	14.3 ± 4.3**	15.94 ± 3.29
	Telmisartan	Sham	1.40 ± 0.06	4.52 ± 0.42	4.65 ± 0.25	7.9 ± 0.43	10.53 ± 1.14
		TBI	1.31 ± 0.06	4.59 ± 0.20	4.83 ± 0.31	11.4 ± 0.9**	11.74 ± 1.28
Ipsilateral cortex	Vehicle	Sham	1.54 ± 0.12	3.46 ± 0.26	4.78 ± 0.54	6.5 ± 0.60	7.06 ± 2.02
		TBI	1.35 ± 0.03*	3.77 ± 0.18	4.36 ± 0.34	53.3 ± 11.3**	16.79 ± 1.7**
	Telmisartan	Sham	1.53 ± 0.10	3.72 ± 0.23	4.55 ± 0.35	13.6 ± 6.16	7.92 ± 1.19
		TBI	1.34 ± 0.06*	3.64 ± 0.29	4.83 ± 0.46	34.1 ± 5.2**	15.73 ± 1.9**
Contralateral hippocampus	Vehicle	Sham	1.86 ± 0.10	5.90 ± 0.51	9.79 ± 0.88	13.9 ± 1.57	22.13 ± 3.23
		TBI	1.92 ± 0.10	6.58 ± 0.40	10.36 ± 0.59	32.5 ± 4.4**	27.40 ± 3.84
	Telmisartan	Sham	1.97 ± 0.46	6.04 ± 0.31	9.78 ± 0.70	9.9 ± 1.21	23.30 ± 2.56
		TBI	2.09 ± 0.06	6.03 ± 0.34	10.50 ± 0.52	27.2 ± 2.7**	31.43 ± 5.17
Ipsilateral hippocampus	Vehicle	Sham	1.77 ± 0.10	6.75 ± 0.34	7.77 ± 0.45	11.7 ± 0.56	17.65 ± 2.54
		TBI	1.57 ± 0.07*	6.63 ± 0.39	5.84 ± 0.67*	62.3 ± 10.6**	31.47 ± 6.16*
	Telmisartan	Sham	1.80 ± 0.46	6.25 ± 0.51	7.70 ± 0.34	11.0 ± 0.41	19.40 ± 2.66
		TBI	1.58 ± 0.06*	6.61 ± 0.27	6.36 ± 0.32	75.6 ± 5.4**	27.08 ± 4.57*

Data are presented as relative ratio of tested gene/cyclophilin and shown as mean ± SE (n = 9–10 per group).

*P < 0.05 compared with Sham within the same drug treatment in the same brain area.

**P < 0.01 compared with Sham within the same drug treatment in the same brain area.