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. 2017 Sep 15;7:11693. doi: 10.1038/s41598-017-10198-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of possible drug effects on viremia and AST dynamics. The inhibitory activity of favipiravir and ribavirin are represented by ε and γ, respectively. Favipiravir inhibits viral production by decreasing the viral production rate p. We test several hypotheses regarding the unknown mode of action of ribavirin: (a) ribavirin affects the transmission of virions, β (model A), (b) ribavirin adds to the effect of favipiravir decreasing viral production, p (model B), (c) ribavirin decreases the death rate of infected cells (model C), and (d) ribavirin increases the death rate of infected cells δ _I, e.g. by enhancing the host’s immune response (model D).