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. 2017 Sep 15;7:11693. doi: 10.1038/s41598-017-10198-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Individual data and model fits for VL dynamics until the end of treatment. Measured data are depicted in symbols, and the gray solid line shows the best fit of model C for each individual mouse. Depicted are all doses used for mono-therapy: PBS (placebo, filled circles); Favipiravir 75 (open triangles), 150 (open circles), and 300 (open squares) mg/kg; and ribavirin 80 (filled squares), and 160 (filled triangles) mg/kg.