Table 4.

Sensitivity analysis for different values of Hill coefficients n_R for ribavirin in model C.

	nF = 1			nF = 3.5
	nR = 2	nR = 3	nR = 4	nR = 1	nR = 2	nR = 3	nR = 4
R 0	5.13 (12)	4.66 (11)	5.29 (12)	4.77 (12)	5.29 (10)	4.88 (9)	5.72 (13)
δ I (/day)	0.58 (14)	0.65 (14)	0.56 (13)	0.63 (14)	0.56 (15)	0.62 (10)	0.52 (14)
p (FFU/day)	1.88 (20)	2.02 (19)	1.89 (17)	1.86 (21)	1.84 (17)	2.04 (18)	1.84 (18)
α (×10−4)	18.2 (15)	17.5 (14)	18.5 (15)	18.2 (14)	1.81 (14)	16.5 (15)	17.2 (15)
s x (U/l)	67.1 (6)	67.2 (6)	68.1 (6)	66.9 (6)	66.6 (6)	67.4 (6)	67.9 (6)
${\mathrm{ED}}_{\mathrm{50}}^{\mathrm{F}}$ (mg/kg)	3.46 (49)	4.88 (47)	3.43 (46)	5.61 (30)	38.6 (13)	43.3 (9)	39.2 (14)
${\mathrm{ED}}_{\mathrm{50}}^{\mathrm{R}}$ (mg/kg)	26.2 (15)	40.9 (11)	51.4 (11)	44.9 (14)	26 (15)	43.3 (13)	54 (11)
σ a (log10 FFU/ml)	0.698 (7)	0.683 (8)	0.679 (7)	0.74 (7)	0.731 (7)	0.71 (7)	0.678 (7)
σ b (U/l)	0.219 (11)	0.221 (11)	0.238 (11)	0.22 (11)	0.226 (11)	0.22 (11)	0.238 (11)
BIC	2193.73	2133.3	2146.5	2135.41	2136.98	2137.46	2145.93

For favipiravir, a Hill coefficient of n_F = 1 and n_F = 3.5⁴⁴ was chosen.

The mean of the estimated parameters with their respective relative standard errors (in %) are shown. For the analysis, we expressed the dose-dependent- efficacies as: $\epsilon ={\mathrm{D}}_{\mathrm{F}}^{{\mathrm{n}}_{\mathrm{F}}}/({\mathrm{D}}_{\mathrm{F}}^{{\mathrm{n}}_{\mathrm{F}}}{+(\mathrm{ED}}_{\mathrm{50}}^{\mathrm{F}}{)}^{{\mathrm{n}}_{\mathrm{F}}})$ for favipiravir, and $\gamma ={\mathrm{D}}_{\mathrm{R}}^{{\mathrm{n}}_{\mathrm{R}}}/({\mathrm{D}}_{\mathrm{R}}^{{\mathrm{n}}_{\mathrm{R}}}+{{(\mathrm{ED}}_{\mathrm{50}}^{\mathrm{R}})}^{{\mathrm{n}}_{\mathrm{R}}})$ for ribavirin. This sensitivity analysis was carried out with fixed T ₀ = 10⁶ cells/ml and V ₀ = 10 FFU/ml.