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. 2017 Aug 19;148(4):395–406. doi: 10.1007/s00418-017-1604-2

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — rBM-plastic interface migration assay. a Assay design. b Overviews of U-251 and E-98 cells after 2 days of radial migration from spheroids under rBM in neurobasal media. Arrowheads, focal cell–cell interactions. c Average migration distance of U-251 and E-98 cells under rBM. Values display median (black line), 25/75 percentiles (boxes) and maximum/minimum (whiskers) from three independent experiments. d Molecular topology of adherens junction proteins in U-251 and E-98 cells migrating under rBM. Images were obtained by epifluorescence (b) and confocal microscopy (d). e Maximum z-projection of U-251 and E-98 cells after 2 days of emigration from multicellular spheroids maintained on polystyrene surface coated with rBM. Scale bars 100 μm (b), 20 μm (zoomed insert b), 50 μm (d,e)