Table 4.

Dose proportionality parameters

Parameters	α	β (90% CI)	ɛ
C max	2.727	−0.118 (−0.29 to 0.052)	0.038
AUC0–2h	2.406	−0.001 (−0.159 to 0.150)	0.032
AUC0–T	2.588	0.124 (−0.132 to 0.380)	0.087
AUC0–∞	2.867	0.079 (−0.176 to 0.334)	0.086

AUC area under the plasma concentration–time curve, AUC _0–T AUC from baseline through the last measured concentration, AUC _0–2h AUC from baseline through 2 h post-dose, AUC _0–∞ AUC extrapolated to infinity, CI confidence interval