Table 4.
Association of CCL2 rs13900 and rs1024611 polymorphisms with congenial CMV-related sensorineural hearing loss (SNHL) at birth and at the age of 6 months follow-up
| Hearing status by ABR | CCL2 genotype a | SNHL n (%) |
Normal hearing n (%) |
OR (95% CI) | P - value | OR (95% CI) | P - value b |
|---|---|---|---|---|---|---|---|
| At birth (n = 56) | |||||||
| rs13900 | CC | 6 (27.3) | 19 (55.9) | 1 | 0.033 | 1 | 0.028 |
| CT/TT | 16 (72.7) | 15 (44.1) | 3.38 (1.06–10.74) | 3.59 (1.10–11.73) | |||
| rs1024611 | AA | 7 (31.8) | 20 (58.8) | 1 | 0.046 | 0.036 | |
| AG/GG | 15 (68.2) | 14 (41.2) | 3.06 (0.99–9.45) | 3.33 (1.05–10.62) | |||
| At the age of 6 months (n = 42) | |||||||
| rs13900 | CC | 4 (26.7) | 16 (59.3) | 1 | 0.04 | 1 | 0.039 |
| CT/TT | 11 (73.3) | 11 (40.7) | 4.0 (1.01–15.87) | 4.10 (1.01–16.59) | |||
| rs1024611 | AA | 5 (33.3) | 17 (63) | 1 | 0.064 | 1 | 0.057 |
| AG/GG | 10 (66.7) | 10 (37) | 3.40 (0.90–12.83) | 3.59 (0.93–13.90) | |||
aStrong linkage disequilibrium was observed between two SNP in the CCL2 gene rs13900 and rs1024611, (D’ = 1, r2 = 0.96)
b P-value calculated for regression model adjusted for variable symptoms at birth