Fig. 8.

Alterations in the expression of splicing factors in cancer. A pan-cancer analysis using TCGA data revealed 132 splicing factors differentially expressed between tumour and normal samples (x-axis). Patterns of upregulation and downregulation across different tumor types (y-axis) are shown in green and violet gradients, respectively. The color intensity indicates the log2-fold change (log2 FC). Splicing factors are clustered into three groups according to the incidence of each expression pattern in the analysed tumours: frequently downregulated (left), frequently upregulated (right), and tendency to show an opposite pattern between the three kidney and the rest of tumor types (Opposing). The bar plot in the top indicates the frequency of tumor types with up-(green) or down-(violet) regulation for each factor. Kidney Chr, kidney chromophobe; Kidney RC, kidney renal clear cell carcinoma; Kidney RP, kidney renal papillary cell carcinoma; Lung Ad, lung adenocarcinoma; Lung Sq, lung squamous cell carcinoma. Image adapted with permission, from Sebestyén et al. (2016)