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. 2017 Sep 14;11:1179069517726996. doi: 10.1177/1179069517726996

Figure 7.

Figure 7.

Slick KO mice exhibit sustained thermal hyperalgesia during chronic inflammatory model. (A) Hargreaves plantar test of persistent inflammatory pain model of complete Freund’s adjuvant (CFA) injection into the hind paw of male and female adult Slick mice. Ipsilateral paw to the injected paw and contralateral paw to the uninjected paw. WT Saline: n = 5, WT CFA: n = 7, KO Saline: n = 4, KO CFA: n = 5. Statistics by 2-way ANOVA multiple comparisons RM; significant difference in both genotype and condition. For comparison of each testing day to average pooled baseline measurements from Figure 5C (WT [double black line], KO [double red line]), statistics by t test. *WT, #KO. **P ≤ .01; ****P ≤ .0001. (B and C) Formalin acute inflammatory model for nocifensive behavior. (B) Average licking and lifting behavior scored per minute over 60 minutes. (C) Average behavior grouped between Phase I (0-10 minutes) and Phase II (15-60 minutes). Statistics by 2-way ANOVA multiple comparisons RM least significant difference. Error bars by SEM. *WT vs KO: **P ≤ .01; *P ≤ .05. ANOVA indicates analysis of variance; KO, knockout; SEM, standard error of the mean; WT, wild type.