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. 2017 Sep 11;10:4455–4464. doi: 10.2147/OTT.S130378

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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miR-509-5p directly targeted MDM2 to exert its effect.

Notes: (A) Sequences of miR-509-5p binding sites within the human MDM2 3′UTR and schematic reporter constructs. (B) Analysis of the relative luciferase activities of MDM2-WT and MDM2-Mut in 293T cells transfected with miR-509-5p mimic or scramble control. *P<0.05 (mean ± SD) vs scramble control. (C) Real-time quantitative reverse transcription polymerase chain reaction analysis of MDM2 mRNA expression in PANC-1 cells transfected with miR-509-5p mimic or scramble control. The results are expressed relative to the control value. *P<0.05 (mean ± SD) vs scramble control.