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. 2017 Sep 13;8:638. doi: 10.3389/fphar.2017.00638

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Copyright © 2017 Gentile, Lazzerini, Gamberucci, Natale, Selvi, Vanni, Alì, Taddeucci, Del-Ry, Cabiati, Della-Latta, Abraham, Morales, Fulceri, Laghi-Pasini and Capecchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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P2X7R stimulation induces CTGF release from dermal fibroblasts, which is completely abrogated by P2X7R antagonism or ERK-1/2 inhibition. Effect of Bz+LPS stimulation on CTGF release in the culture medium of dermal fibroblasts from SSc patients (n = 2) and healthy controls (n = 2), as determined by ELISA assay, and its modulation by P2X7R antagonists (oATP 200 μM; A438079 10–50 μM) or an ERK-1/2 inhibitor (FR-180204 50 μM). CTGF, connective tissue growth factor; SSc, Systemic sclerosis; P2X7R, P2X7 receptor; B, baseline; Bz, 2′-3′-O-(4-benzoylbenzoyl)ATP; LPS, lipopolysaccharide; oATP, oxidized ATP; A43[50], A438079 50 μM; A43[10], A438079 10 μM; FR, FR-180204.