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. 2017 Jun 15;292(37):15254–15265. doi: 10.1074/jbc.M117.778530

Figure 6.

Figure 6.

Defective abscission in SCCRO−/− MEFs leads to a delay in and failure of abscission. A, long-term imaging of cell division of SCCRO+/+ and SCCRO−/− MEFs stably expressing Aurora B-EGFP and mCherry–α-tubulin. Compared with SCCRO+/+ MEFs (first row, 83% of cells completed abscission in 60 min or less), defects in SCCRO−/− MEFs include delayed abscission (second row, 82% of cells took >75 min to complete abscission), regression of abscission furrow (third row), multipolar spindle formation (fourth row), and development of polyploidy giant cells (fifth row). Scale bar = 5 μm. B, asymmetric division and, eventually, apoptosis of SCCRO−/− MEFs. 1 and 2 denote the two daughter cells resulting from asymmetric division.