Figure 7.

Structural comparison of a salivary D7 protein (AnStD7L1) and mJHBP. A, ribbon diagram of AnStD7L1 with the N-terminal domain colored light blue, the C-terminal domain colored red, and the extreme C terminus including helix α13 colored green. The leukotriene C₄ ligand (LTC₄) is shown in stick representation with carbon colored blue and oxygen red. B, mJHBP oriented and colored as in panel A with the JH III ligand shown in stick representation with carbon colored cyan and oxygen red. In the case of mJHBP, the C-terminal portion including helix α13 is positioned to cover the entry to the binding pocket. C, space filling representation of panel A to show the open entry to the N-terminal domain binding pocket that accommodates the 20-carbon fatty acid of leukotriene C₄. D, the space filling model of mJHBP, oriented as in panel B, shows nearly complete burial of the bound ligand and occlusion of the entry channel.