Table 5.
Discovery cohort | Eosinophil (%) | Neutrophil (%) | Lymphocyte (%) | Macrophage (%) |
---|---|---|---|---|
ACO versus COPD | ||||
AUC (95% CI) | 0.708 (0.633–0.782) | 0.271 (0.2–0.342) | 0.433 (0.354–0.513) | 0.660 (0.583–0.736) |
Cutoff (%) | 3.55 | 84.55 | 5.76 | 4.63 |
Sensitivity/specificity (%) | 59.7/72.5 | 37.5/23.7 | 97/12 | 58.3/69.4 |
p-value | <0.001 | <0.001 | 0.104 | <0.001 |
Asthma versus COPD | ||||
AUC (95% CI) | 0.673 (0.612–0.733) | 0.234 (0.18–0.288) | 0.393 (0.329–0.456) | 0.746 (0.69–0.802) |
Cutoff (%) | 8.95 | 76.4 | 1.77 | 5.33 |
Sensitivity/specificity (%) | 38.7/88.7 | 44.4/11.2 | 22.5/60 | 65.5/72.5 |
p-value | <0.001 | <0.001 | 0.001 | <0.001 |
ACO versus asthma | ||||
AUC (95% CI) | 0.518 (0.438–0.598) | 0.585 (0.508–0.661) | 0.541 (0.458–0.623) | 0.389 (0.312–0.466) |
Cutoff (%) | 1.11 | 70.66 | 1.64 | 7.16 |
Sensitivity/specificity (%) | 84.7/25.4 | 69.4/50 | 34.7/76.1 | 36.1/43 |
p-value | 0.668 | 0.43 | 0.33 | 0.008 |
Abbreviations: ACO, asthma–COPD overlap; AUC, area under the curve; ROC, receiver operating characteristic.