Figure 5.
In vivo MR imaging.
Notes: Representative in vivo serial T1-weighted MR images (A) before and at 1, 2, and 4 h postinjection of targeted Gd2O3-FI-PEG-BBN or non-targeted Gd2O3-FI-PEG and pseudocolor maps of MR images 2 h after administering each agent. Quantitative analysis of signal intensity in the tumor region (B) of PC-3 tumor-bearing mice before and 2 h after intravenous injection. Schematic representation (C) of GRPR-mediated intracellular delivery. *P<0.05.
Abbreviations: BBN, bombesin; FI, 5(6)-carboxyfluorescein; Gd2O3, gadolinium oxide; GRPR, gastrin-releasing peptide receptor; MR, magnetic resonance; PEG, polyethylene glycol.