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. 2017 Sep 12;12:6787–6797. doi: 10.2147/IJN.S139246

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© 2017 Cui et al. This work is published and licensed by Dove Medical Press Limited

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In vivo MR imaging.

Notes: Representative in vivo serial T1-weighted MR images (A) before and at 1, 2, and 4 h postinjection of targeted Gd₂O₃-FI-PEG-BBN or non-targeted Gd₂O₃-FI-PEG and pseudocolor maps of MR images 2 h after administering each agent. Quantitative analysis of signal intensity in the tumor region (B) of PC-3 tumor-bearing mice before and 2 h after intravenous injection. Schematic representation (C) of GRPR-mediated intracellular delivery. *P<0.05.

Abbreviations: BBN, bombesin; FI, 5(6)-carboxyfluorescein; Gd₂O₃, gadolinium oxide; GRPR, gastrin-releasing peptide receptor; MR, magnetic resonance; PEG, polyethylene glycol.