Table 3.

Logistic regression analyses of factors associated with major depression

Characteristic	Associations with depression prevalence – odds ratios (95% CI) displayed for simultaneously entered covariates
	Unadjusted	Adjusted model 1a	Adjusted model 2b	Adjusted model 3c	Final model 4d
Age, years	0.96 (0.92–1.01)	0.96 (0.92–1.01)	0.98 (0.92–1.05)	0.98 (0.92–1.05)	0.96 (0.91–1.01)+
Psychosocial factors
Insomnia (yes/no)	2.95 (1.26–6.92)*	2.38 (0.97–5.89)+	2.22 (0.87–5.65)+	2.44 (0.94–6.36)+	2.01 (0.78–5.15)
Psychiatric family history (yes/no)	3.81 (1.37–10.6)*	2.13 (0.71–6.43)	–	–	–
Pain severity (score)	1.29 (1.11–1.50)**	1.25 (1.07–1.47)**	1.32 (1.12–1.57)**	1.32 (1.11–1.56)**	1.27 (1.08–1.49)**
Cancer-related factors
Menopause (yes/no)	0.41 (0.18–0.94)*	–	0.50 (0.15–1.67)	0.43 (0.12–1.52)	–
Duration of breast cancer (years)	0.31 (0.12–0.84)*	–	0.31 (0.11–0.89)*	0.45 (0.15–1.40)	–
Treatment
Radiation therapy (yes/no)	3.05 (1.11–8.37)*	–	–	4.61 (1.40–15.1)*	5.53 (1.69–18.06)**
Hormone therapy (yes/no)	0.43 (0.19–0.98)*	–	–	0.32 (0.11–0.93)*	0.23 (0.08–0.62)**
Family support (score)	0.84 (0.75–0.93)***	–	–	–	0.87 (0.78–0.98)*

Notes:

^aAdjusted for age, insomnia, psychiatric family history, and pain severity;

^bAdjusted for age, insomnia, pain severity, menopause (yes/no), and duration of breast cancer (years);

^cAdjusted for age, insomnia, pain severity, menopause (yes/no), duration of breast cancer (years), radiation therapy (yes/no), and hormone therapy (yes/no);

^dAdjusted for age, insomnia, pain severity, radiation therapy (yes/no), hormone therapy (yes/no), and family support. Statistically significant

⁺0.05<p<0.10,

^*p<0.05,

^**p<0.01,

^***p<0.001. ‘–’, variables were not included in multiple logistic regression.