Table 1.
Correlation between OS and clinical features of PDAC patients
| Variables | Patients (n=112) |
MST (days) |
HR (95% CI) | Log-rank P-value |
|---|---|---|---|---|
| Age (years) | ||||
| ≤60 | 38 | 593 | 1 | 0.066 |
| >60 | 74 | 485 | 1.636 (0.962–2.780) | |
| Gender | ||||
| Female | 53 | 511 | 1 | 0.523 |
| Male | 59 | 592 | 0.855 (0.529–1.382) | |
| Alcohol historya | ||||
| No | 43 | 592 | 1 | 0.349 |
| Yes | 61 | 511 | 1.276 (0.765–2.128) | |
| Pathologic stage | ||||
| Stage I | 8 | 236 | 1 | 0.943 |
| Stage II | 104 | 518 | 1.038 (0.375–2.872) | |
| Pathologic T | ||||
| T1/T2 | 14 | 498 | 1 | 0.466 |
| T3 | 98 | 518 | 1.340 (0.608–2.949) | |
| Pathologic N | ||||
| N0 | 21 | 634 | 1 | 0.091 |
| N1 | 91 | 511 | 1.818 (0.899–3.678) | |
| Histologic grade | ||||
| G1 | 15 | 518 | 1 | 0.034 |
| G2 | 65 | 603 | 1.220 (0.540–2.755) | |
| G3/G4 | 32 | 470 | 2.267 (0.962–5.341) | |
| Radical resectionb | ||||
| No | 44 | 603 | 1 | 0.009 |
| Yes | 66 | 381 | 0.514 (0.310–0.852) | |
| Radiation therapyc | ||||
| No | 70 | 473 | 1 | 0.029 |
| Yes | 30 | 691 | 0.527 (0.293–0.947) | |
| Targeted molecular therapyd | ||||
| No | 29 | 224 | 1 | <0.001 |
| Yes | 73 | 634 | 0.168 (0.095–0.296) | |
Notes:
a
Alcohol history information unavailable for 8 patients.
b
Radical resection information unavailable for 2 patients.
c
Radiation therapy information unavailable for 12 patients.
d
Targeted molecular therapy information unavailable for 10 patients.
Abbreviations: OS, overall survival; PDAC, pancreatic ductal adenocarcinoma; MST, median survival time; HR, hazard ratio; CI, confidence interval.