Table 1. Experimental designs and protocolsa.
| Acute UC model | Chronic UC model | |
|---|---|---|
| UC induction by DSS | 3.0% (w/v) DSS (5 d) | 4 cycles of 2.5% (w/v) DSS for 3 d, with alternate autoclaved water for 6 d in between (30 d in total) |
| Dosing method | Oral gavage | Oral gavage |
| Treatment period | 7 d | 14 d |
|
Experimental design |
Group 1) Water/vehicle (healthy control) Group 2) DSS/vehicle (disease control) Group 3) DSS/MSE (MSE treatment; 150 mg/kg bw of MSE) Group 4) DSS/5-ASA (positive control; 50 mg/kg bw of 5-ASA) |
|
a Modified based on Dey et al., 2010 [26]