Table 2.
Positive and negative predictive values of ARR cutoffs for the diagnosis of PAa in the full cohort, with (BMI ≥30 kg/m2) and without (BMI <30 kg/m2) obesity
| ARR cutoff | ≥20 or <20 | ≥30 or <30 | ||
|---|---|---|---|---|
| PPV, % | NPV, % | PPV, % | NPV, % | |
| All patientsb (N=46) | 84.6 | 65.0 | 77.8 | 46.4 |
| BMI ≥30 (n=29) | 76.5 | 58.3 | 63.6 | 38.9 |
| BMI <30 (n=17) | 100 | 75.0 | 100 | 60.0 |
a
Primary aldosteronism (PA) was diagnosed according to PA concentration >10 ng/dL following administration of 2 L of sodium chloride 0.9% over 4 hours, or according to urinary aldosterone collection >12 μg/24 h following oral sodium loading in the presence of urinary sodium >200 nmol/24 h.
b
Only patients who underwent case validation tests.
Abbreviations: ARR, aldosterone to renin ratio; BMI, body mass index; NPV, negative predictive value; PPV, positive predictive value.